apalutamide will reduce the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with drugs that happen to be CYP2C19 substrates may end up in decrease exposure to these remedies.amobarbital will reduce the level or influence of d